Maisonneuve-Rosemont Hospital Université de Montréal

Aplastic anemia

SEVERE APLASTIC ANEMIA

Definition

Bone marrow cellularity inferior to 30% and at least 2 of the following 3 features:

Transplantation indications

Related donor transplant
a) Up until age 40:
1st choice if 6/6 HLA identical related donor

b) 41-60 years old:
If patient is refractory to conventional immunosuppressive therapy (treatment must have included ATG and a calcineurin inhibitor)

Unrelated donor transplant
Up until age 60:
If patient is refractory to conventional immunosuppressive therapy (treatment must have included ATG and a calcineurin inhibitor)

Non severe aplastic anemia

Definition

Transplantation indication