Dr. Guy Sauvageau
Titles
- Chief Executive Officer and Scientific Director, Institute for Research in Immunology and Cancer
- Full Professor, Department of Medicine, Faculty of Medicine, Université de Montréal.
- Clinical researcher, Haematologist, Stem cell transplant center, department of Haematology, Maisonneuve-Rosemont Hospital.
- Vice-president (2009-2010) scientific committee American Society of Hematology, stem cell section.
- Chair, Research counsil of Canada on molecular genetics of stem cells.
- Principal investigator, Molecular Genetics of Stem Cells Laboratory, IRIC.
- Adjunct Professor, Department of experimental Medicine, McGill University.
- Co-Director and founder Quebec Leukemia Cell Bank .
Training
- Ph.D. Medicine: Université de Montréal, 1987.
- M.Sc. in Immunovirology, Université de Montréal, 1988.
- Fellow, Royal College of Physician and Surgeon of Canada, Internal medicine, 1991, Hematology 1992.
- Ph.D. experimental medicine, University of British-Columbia, 1995.
- Postdoctoral training with Keith R. Humphries, Terry Fox Laboratory, BC Cancer Research Center, 1996.
Research and teaching
Main domain of research
Dr. Sauvageau is a researcher and clinical practitioner, specializing in the transplant of bone marrow-derived stem cells, called hematopoietic stem cells, and in the study of the molecular mechanism involved in their self-renewal. A disruption of the production mechanism of these cells is responsible for a large variety of human illnesses and clinical problems. For example, uncontrolled growth of bone marrow stem cells causes leukemia; our current inability to stimulate their renewal is a serious impediment to successful human bone marrow transplants.
Over the last fifteen years, Dr. Sauvageau’s work has led to ground-breaking discoveries in understanding the production of hematopoietic stem cells. With his research team, he identified the potential of the HOXB4 and Bmi1 genes which are instrumental in regulating the self-renewal of these cells. His laboratory uses approaches in functional screening to identify genetic networks implicated in this process.
Research support
Canadian Health Research Institute, Génome Québec, Canadian Cancer Society Research Institute, National Institutes of Health, Stem Cell Network, The Leukemia and Lymphoma Society.
Research projects with grants
- Peer-reviewed organisms: 8
Influential
Scientific presentations and conferences
- 136.
Awards and honours
- Till and McCulloch Award from International Society of Hematology, 2006.
- Stohlman Scholar Award of the Leukemia Lymphoma Society (USA), 2007.
- Fellow Canadian Academy of Health Sciences, 2008.
