Maisonneuve-Rosemont Hospital Université de Montréal

Dr. Guy Sauvageau



Research and teaching

Main domain of research

Dr. Sauvageau is a researcher and clinical practitioner, specializing in the transplant of bone marrow-derived stem cells, called hematopoietic stem cells, and in the study of the molecular mechanism involved in their self-renewal. A disruption of the production mechanism of these cells is responsible for a large variety of human illnesses and clinical problems. For example, uncontrolled growth of bone marrow stem cells causes leukemia; our current inability to stimulate their renewal is a serious impediment to successful human bone marrow transplants.

Over the last fifteen years, Dr. Sauvageau’s work has led to ground-breaking discoveries in understanding the production of hematopoietic stem cells. With his research team, he identified the potential of the HOXB4 and Bmi1 genes which are instrumental in regulating the self-renewal of these cells. His laboratory uses approaches in functional screening to identify genetic networks implicated in this process.

Research support

Canadian Health Research Institute, Génome Québec, Canadian Cancer Society Research Institute, National Institutes of Health, Stem Cell Network, The Leukemia and Lymphoma Society.

Research projects with grants


Scientific presentations and conferences

Awards and honours