Maisonneuve-Rosemont Hospital Université de Montréal

Myelodysplastic syndrome

International prognosis scoring system

Prognosis factors Score
0 0,5 1 1,5 2,0
Cytopeniasaa 0 – 1 2 – 3      
Karyotypeb good intermediate poor    
% marrow blasts < 5 5 – 10   11 – 20 21 – 30

Median survival

Risk category Combined score Median survival if ≥ 60 years
Low 0 11,8 years
Intermediate – 1 0,5 – 1,0 5,2 years
Intermediate – 2 1,5 – 2,0 1,8 years
High ≥ 2,5 0,3 years
aCytopenias:  
neutrophils
platelets
hemoglobin
< 1.5 x 109/L
< 100 x 109/L
< 100g/L
bKaryotype:  
Good
Poor
Intermediate
normal, -Y, del (5q), del (20q)
complex (≥ 3 abnormalitiess) or abnormal chromosome 7
others abnormalities

Indications for allogeneic transplant

5q- syndrome

Age limitation and transplantation

Blasts in bone marrow

Myeloablative vs nonmyeloablative transplant